Serpentis is the legacy of Set, his gift to his children. The Followers of Set carefully guard this discipline's secrets, teaching the reptilian art only to those deem worthy. Most Cainites fear the Setites purely because of this discipline, the way of the serpent and the temper. Serpentis can evoke an almost primordial fear in others, particularly those who recall the tale of Eden. After all, the serpent was evil and older than even Caine himself.

The vampire may paralyze anyone with whom she makes eye contact, for as long as eye contact is maintained. When the vampire first learns this power, her eyes change into those of a serpent. This is considered a permanent change, thought the exact nature of the change varies.

The vampire may change her tongue into that of a serpent, being about eighteen inches long and forked. This tongue can be used to inflict aggravated damage, or to drink blood. This should be considered equivalent to the Kiss, including the pleasure caused in those on whom it used.

The vampire may enter a form of torpor, in which she is only vulnerable to sunlight and fire, but completely inert. No other damage will affect the vampire in this state. This change takes one turn, and he/she must taste the blood of another to awaken.

By paying one blood point over three turns, the vampire can transform into a black, poisonous cobra, of about six feet in length. This may also be done by paying three blood points over one turn if the vampire's generation allows it. In this state, all Perception rolls involving smell are rolled with their difficulties decreased by two, but all Perception rolls involving hearing are rolled with their difficulties increased by two.

The vampire may remove his/her heart on the new moon, and put it in a clay urn. He/she may even do this to another vampire, though this takes several hours. For the vampire to whom this is done, it makes her unstakable. If the heart is destroyed, she will die horribly. If the heart is staked, he/she will enter torpor.

By describing her victim's lusts to him/her, the vampire may cause a victim to be obsessed with something. The victim will try to fulfill her lusts nightly, and may frenzy if unsatisfied. This should be treated as a derangement, and may be overcome as such.

By describing her victim's weakness to him/her, the vampire may encourage a victim to behave in a corrupt and decadent fashion, even if he/she may lose Humanity as a result. This should be treated as a derangement, and may be overcome as such.

By describing his/her victim's fears to him/her, the vampire may give a victim a phobia, which may be of anything.

By touching his/her victim, the vampire may corrupt the victim, instilling a fondness for the Beast, and feelings of sadism. The vampire automatically loses on Humanity for doing this if his/her Humanity is above three.

An inanimate object may be infused with power Corruption, as detailed above, but the vampire automatically loses one Humanity for committing this act. Such an object affects anyone it touches who would normally be subject to this power, and if the vampire learns about the victims of the object.

By touching the forehead of his/her victim, the vampire may disfigure a target so horribly that all characters who see her must accumulate five successes over three Self-control rolls, at difficulty 8, to refrain from attacking him/her. (He/she must roll likewise if she sees himself/herself in a mirror, to avoid smashing the mirror.) This may be cured only by powerful rituals or the consent of the vampire.